This study can reveal a reliable sign of actinomycosis - actinomycete drusen located in the center of microabscesses. They are radiant formations with characteristic "cones" at the ends, which consist of thickened filaments of mycelium. In pathological fabrics the characteristic phenomenon of Hoeppli — Splendore also comes to light. It is presented in the form of microabscesses surrounded by granulation tissue, eosinophilic granulocytes, giant and Metformin cells.
Therefore, they do not grow on nutrient media even with clinically typical actinomycotic inflammation.
Histological examination of the material allows for differential diagnosis of actinomycetes with other bacteria. For this, the material is stained with one of the special methods. According to clinical symptoms without laboratory confirmation, the diagnosis of actinomycosis can only be made by an experienced doctor who is well acquainted with this pathology, based on the characteristic specific features of this disease, using glucophage pills, CT and ultrasound studies.
Fistulography is an important radiological method for diagnosing actinomycosis. With its help, you can find out how common the pathological process is. The simultaneous use of this method in conjunction with urography and irrigoscopy for genital and genital-abdominal actinomycosis allows you to determine the localization of foci, the branching of the fistulous passages and the depth of the lesion. Abdominal actinomycosis is characterized by the absence of damage to the intestinal mucosa, even against the background of an existing filling defect in the intestine. This distinguishes actinomycosis from a tumor.
With abdominal actinomycosis, irrigoscopy reveals characteristic connective tissue constrictions extending from the infiltrate in the abdominal cavity to the intestinal wall, in the form of so-called spicules and serrations, which are sometimes called the "saw symptom".
Changes in bone tissue in actinomycosis have their own special features: areas of increased density alternate with areas of destruction (resorption) of bones, rounded defects in the form of honeycombs or "punch holes" and others are found. Ultrasound with actinomycosis may be required to determine the localization of the focus, its size and density.
Each form of actinomycosis should be excluded other similar diseases: Anti-inflammatory antimicrobial therapy is carried out taking into account the sensitivity of the accompanying microflora to drugs.
Penicillin is used at a dose of 10-20 million units per day, but it is used less and less because of the developing resistance (resistance) to the drug. Preference is given to cephalosporins, tetracyclines and aminoglycosides.